Glucocorticoids in pregnancy.

Potential significance of physiological and pharmacological glucocorticoids in early pregnancy.

BACKGROUND Despite extensive studies of the developmental consequences of increased glucocorticoid exposure in mid- to late pregnancy, relatively little is known regarding the significance of glucocorticoids in early pregnancy. The objective of this review was to consider potential roles for this family of corticosteroids that might relate to early pregnancy. METHODS Although this is a narrat...

The Role of Glucocorticoids in Pregnancy: Four Decades Experience with Use of Betamethasone in the Prevention of Pregnancy Loss

A Case of Cushing’s Syndrome in Pregnancy

Cushing’s syndrome (CS) occurs rarely during pregnancy. CS can be caused by prolonged abnormal exposure to excess glucocorticoids leading to special and significant signs and symptoms. It is often difficult to diagnose pathological hypercortisolism in pregnant women since some symptoms of the disease might be due to a complicated pregnancy, including preeclampsia or gestational diabetes. In thi...

Metabolism of synthetic steroids by the human placenta.

Pregnant women with asthma are frequently exposed to synthetic glucocorticoids and glucocorticoids are known to reduce fetal growth. The fetus is normally protected from the harmful effects of maternally derived glucocorticoids by the placental enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2). Whether 11beta-HSD2 inactivates the synthetic glucocorticoids used for asthma treatment...

Low-pressure headache presenting in early pregnancy with dramatic response to glucocorticoids: a case report

INTRODUCTION Obstetricians are familiar with postural headaches in their postpartum patients following spinal or epidural anaesthesia. The rare occurrence in the antepartum patient without inciting event, may pose a diagnostic and treatment dilemma with resultant prolongation of disabling headaches in affected patients. Awareness of this condition, if accurately diagnosed, may allow for earlier...

The effect of stress and glucocorticoids on modulation of pain in mice: Interaction with activation of voltage dependent Ca2+ channel

Previous studies indicated that stress and glucocorticoids have modulatory effects on acute pain. The aim of present study was to determine the interaction between stress and glucocorticoids with activation of voltage dependent Ca2+ channel on modulation of acute pain in mice. Male albino mice (25-30 g) were used for this experiment. Tail flick and hot plate were used for evaluation of analgesi...